(c)+DNA+replication

Hanna = What is DNA Replication? =

DNA replication is a vital part of cell division, when DNA in the chromosomes containing the coded instructions for the characteristic of one organism is copied in order to be passed on to its offspring. This results to biological inheritance.

The Replication Factory

DNA replication process requires the concerted action of many different proteins. The small "Replication Factory" manufactures DNA copies and the incoming DNA double helix is split into two single strands. Each original single strand becomes half of a new DNA double helix.


 * Step 1: The two strands (sides) of the DNA **__separate__** by helicase enzyme.
 * Each strand acts as a **__template (for making another strand using nucleotides)__**.
 * . __Step2:__ **__Nucleotides__** match up against each __**base pairing**.__
 * . We end up with two **__replicated__ __DNA__** strands

Step1: The two strands (sides) of the DNA **__separate__** by helicase enzyme. The point where this process happens is known as the replication fork. Each strand acts as a **__template (for making another strand using nucleotides)__**.
 * Detailed steps with images**

Step2: SSBs coat the single strands to prevent reannealing.



Step3: **__Nucleotides__** match up against each **__base pairing__**__.__ In other word, polymerase attaches nucleotide at 3’ end. Synthesis is in 5’ to 3’ direction.

Step4; DNA polymerase extend nucleic acid chain and Promase synthesizes RNA primers.

Step5: each of the two new strands gets synthesized in the 5’ to 3’ direction. On new strands in synthesized continuously and the other new strand is synthesized discontinuously. And the sliding clamp allows DNA to be processive.



Step6: leading strand is synthesized continuously, and lagging strand is synthesized discontinuously. DNA pieces separated by RNA primes in lagging strand are Okazaki fragments. Step7: RNA primers will be removed by RNase H. The gaps are filled by DNA polymerase and DNA ligase ligates the Okazaki fragments.



Step8: We end up o **__replicated__ __DNA__** strands. =Other Videos, Images and Animations = = DNA Replication Animation: = []

Video on DNA Replicaiton:


= media type="youtube" key="teV62zrm2P0" height="315" width="420" = = = = Works Cited: = "Diagram of DNA Replication." //Portal.unishanoi.org//. Web. 3 Feb. 2012. . "DNA Replication - YouTube." //YouTube - Broadcast Yourself.// Web. 04 Feb. 2012. . "Essential Biochemistry - DNA Replication." //Wiley: Home//. Web. 04 Feb. 2012. . Pickering, W. R. "11.2." //Complete Biology//. Oxford: Oxford UP, 2000. 191. Print. "Replication Simple." //Portal.unishanoi.org//. Web. 3 Feb. 2012. .